Cardiac biomarker detection based on nanostructured biosensors

Shiv Govind Singh, Suryasnata Tripathy

Pdf Page Numbers :- 66-71

Shiv Govind Singh^1,* and Suryasnata Tripathy¹

¹Department of Electrical Engineering, IIT Hyderabad, Telangana, India

*Corresponding author: Dr. Shiv Govind Singh, Department of Electrical Engineering, Indian Institute of Technology Hyderabad, Sangareddy, Kandi, Telangana-502285, India. Email: sgsingh@iith.ac.in

Received 05 January 2017; Revised 13 March 2017; Accepted 22 March 2017; Published 29 March 2017

Citation: Singh SG, Tripathy S. Cardiac biomarker detection based on nanostructured biosensors. J Med Sci Res. 2017; 5(2):66-71. DOI: http://dx.doi.org/10.17727/JMSR.2017/5-13

Copyright: © 2017 Singh SG et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Early and accurate detection of plasma borne cardiac biomarkers is essential for prevention of life threatening acute myocardial infarctions. Development of low cost and point of care platforms that can ensure ultrasensitive detection of cardiac biomarkers is key to this endeavor. In this context, herein, a brief discussion is provided highlighting the contribution of nanotechnology and microfabrication towards the development of such biosensing platforms, targeting the detection of several cardiac biomarkers such as Myoglobin, Troponin T, Troponin I and creatine kinase MB. Furthermore, the challenges associated with the conventional techniques that led to the development of the ultrasensitive biosensors are described in brief. In addition to several prominent nanoscale sensors that ensure very low limit of detection of cardiac biosensors, performance analysis of a conductive nanofiber based cardiac biomarker detection platform developed by our team is presented in this paper.

Keywords: cardiac biomarker;  nanostructured biosensors; myocardial infarctions