Microfluidics for antibody-independent separation of circulating tumor cells

Vijay Duryodhan, Shiv Govind Singh

Pdf Page Numbers :- 61-65

Vijay Duryodhan¹ and Shiv Govind Singh^1,*

¹Department of Electrical Engineering, IIT Hyderabad

*Corresponding author: Dr. Shiv Govind Singh, Department of Electrical Engineering, Indian Institute of Technology Hyderabad, Sangareddy, Khandi, Telangana 502285. Email: sgsingh@iith.ac.in

Received 20 January 2017; Revised 17 March 2017; Accepted 24 March 2017; Published 30 March 2017

Citation: Duryodhan V, Singh SG. Microfluidics for antibody-independent separation of circulating tumor cells. J Med Sci Res. 2017; 5(2):61-65. DOI: http://dx.doi.org/10.17727/JMSR.2017/5-12

Copyright: © 2017 Duryodhan V et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Separation of circulating tumor cells (CTC) from the blood without using antibodies is a key challenge in the diagnosis of cancer. This article has reviewed few antibody-independent techniques governed by cell size on microfluidics platform. Microdevices employing micro-pore filters, dielectrophoresis, acoustophoresis and inertia that is popular in various research labs are studied in detail from the literature and discussed shortly. The inertia based technique in spiral microchannel seems to be more promising towards the development of future point-of-care (POC) microdevices for CTCs separation.

Keywords: antibody-independent separation; circulating tumor cells; microfluidics; microdevices