Seroprevalence of hepatitis C virus antibodies among Sudanese patients with schistosomiasis referred to Al-elafon military hospital in Khartoum state

Faruha MBH, Zienalabdeen R, Gorish BMT, Abdelgalil MAA, Ali MAS, Taha OAA, Elterafi SAY, Mohamed WAA

Pdf Page Numbers :- 93-97

Mohamed Bashir Hussein Faruha¹, Rasha Zienalabdeen¹ , Babbiker Mohammed Taher Gorish^2,*, Mohamed Abdalrahim Ahmed Abdelgalil¹, Mohamed Ali Siddig Ali¹, Omer Abdalgadir Ahmed Taha¹, Sara Abdalhakam Yousif Elterafi¹, and Walla Abdalgfar Albushra Mohamed¹

¹Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, Sudan International University, Sudan

²Department of Medical Microbiology, Faculty of Medical Laboratory Sciences, Omdurman Islamic University, Sudan

*Corresponding author: Babbiker Mohammed Taher Gorish, Ph.D. in Medical Microbiology, Department of Microbiology and Immunology - Faculty of Medical Laboratory Science, Omdurman Islamic University, Sudan. Email: qorish456@gmail.com

*All Authors are equally contributed in this work

Received 22 March 2019; Revised 10 June 2019; Accepted 17 June 2019; Published 24 June 2019

Citation: Faruha MBH, Zienalabdeen R, Gorish BMT, Abdelgalil MAA, Ali MAS, Taha OAA, Elterafi SAY, Mohamed WAA. Seroprevalence of hepatitis C virus antibodies among Sudanese patients with schistosomiasis referred to Al-elafon military hospital in Khartoum state. J Med Sci Res. 2019; 7(3):93-97. DOI: http://dx.doi.org/10.17727/JMSR.2019/7-16

Copyright: © 2019 Faruha MBH et al. Published by KIMS Foundation and Research Center. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Abstract

Background: Hepatitis C virus (HCV) infection and schistosomiasis, has worldwide coexistence especially in Africa. Some researchers suggest that schistosomiasis is the risk factor for the development of HCV infection.

Objective: The current study was aimed to determine seroprevalence of HCV among Sudanese patients with schistosomiasis.

Method: From April 2017 to July 2017, a total of 60 blood samples were obtained from patients who confirmed microscopically with schistosomiasis. The blood samples were centrifuged at 3000 RPM for 5 minutes to obtain serum. All serum samples were screened for the presence of HCV IgG antibody by using indirect ELISA. The samples with positive reaction were confirmed by repeating the test. We used an interviewer-administered questionnaire to ask participants about their demographic data as well as their geographical afflation. Statistical analysis was performed by using SPSS version 20.

Result: All patients were male and aged between 15 to 27 years old with an average of 20.1± 2.25 years. Out of 60 serum samples investigated 3[5%] were positive for HCV IgG antibody, while 56[93.3%] were shown a negative result. Interestingly, we determine one sample 1[1.7%] with borderline reaction.

Conclusion: The study concluded that there was a high seroprevalence of HCV IgG antibody among patients with Schistosoma infection in comparison to the finding of previous researchers who investigate those are not infected. This may suggest a possible association between HCV infection and Schistosoma. Further studies with the inclusion of large sample size and by using a more advanced technique [PCR] should be considered in the future.

Keyword: HCV; schistosomiasis; ELISA